Journal
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
Volume 122, Issue 1, Pages 135-140Publisher
OXFORD UNIV PRESS INC
DOI: 10.1309/UAR9WVFH4AGHM5ME
Keywords
hematopoietic cell; allogeneic HSCT; hematopoietic stem cell transplantation; donor origin; CD16; multidimensional flow cytometry; myelodysplastic syndrome; paroxysmal nocturnal hemoglobinuria
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Funding
- NCI NIH HHS [CA 87948] Funding Source: Medline
- NHLBI NIH HHS [HL 36444] Funding Source: Medline
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Multidimensional flow cytometry found an abnormal lack of CD16 expression detected on neutrophils after hematopoietic stem cell transplantation (HSCT) in bone marrow specimens from. 2 patients. Chimerism studies were used to determine that the CD16- myeloid cells were donor in origin, consistent with a normal polymorphic variant, most likely a previously described Fcgamma receptor IIIB gene deletion. Identical phenotypes were recognized in peripheral blood samples obtained subsequently from the respective donors. These donor-specific phenotypic abnormalities were transferred to patients who underwent successful HSCT The distinction of these phenotypic Tic abnormalities from neoplastic changes such as secondary myelodysplasias or relapse of original disease is important in. posttransplantation monitoring of hematopoietic diseases.
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