Journal
JOURNAL OF PSYCHIATRIC RESEARCH
Volume 38, Issue 4, Pages 365-370Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2004.01.001
Keywords
genetic polymorphism; treatment response; paroxetine
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To clarify the role of catechol-o-methyltransferase (COMT) polymorphism in panic disorder (PD), we investigated a large group of Korean PD patients (N = 178) and controls (N = 182) using a case-control study. We also assessed the response to paroxetine treatment and other clinical variables in the PD patients. The increase in the COMTL allele was not statistically significant in PD (p = 0.104). However, compared with the sum of the other genotypes, the frequency of the L/L genotype was significantly higher in PD (p = 0.042). The odd ratios (ORs) also indicated a significant effect of the homozygosity for the COMTL allele on an increased risk for PD (OR = 2.38; 95% Cl 1.03-5.5 1). In addition, patients with L/L genotype had higher trait-anxiety levels (P = 0.030) and poorer treatment response to paroxetine than those with other genotypes (p = 0.002). Our results suggest that the COMT L/L genotype is associated with PD and the genetic variant of the COMT enzyme may be related to the clinical severity and treatment response to paroxetine in PD. (C) 2004 Elsevier Ltd. All rights reserved.
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