Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 52, Issue 1, Pages 19-26Publisher
BLACKWELL MUNKSGAARD
DOI: 10.1111/j.1600-0897.2004.00177.x
Keywords
cytokines; lymphocytes; men; monocytes; women
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PROBLEM: The purpose of this present ex vivo study is to get insight in the sex differences of the basic non-specific and specific immune response. METHOD OF STUDY: Intracellular types 1 and 2 cytokine production by stimulated male and female lymphocytes and monocytes in a whole blood preparation was measured by flow cytometry. RESULTS: Increased percentage interleukin (IL)-12, IL-1beta and tumor necrosis factor (TNF)-alpha producing monocytes and decreased percentage IL-2 producing lymphocytes, i.e. type 1 cytokine, were found in men as compared with women. CONCLUSION: These results suggest a gender difference in the balance between the specific and non-specific immune response, i.e. a more profound and higher state of excitation of the non-specific immune response and relative suppression of the cellular immune response of the specific immune system in men as compared with women.
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