Journal
EXPERIMENTAL HEMATOLOGY
Volume 32, Issue 7, Pages 585-598Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.exphem.2004.03.013
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Funding
- NINDS NIH HHS [R01 NS034160-05A2, R01 NS034160] Funding Source: Medline
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Stem cells have been identified and characterized in a variety of tissues. In this review we examine possible shared properties of stem cells. We suggest that irrespective of their lineal origin, stem cells have to respond in similar ways to regulate self-renewal and differentiation and it is likely that cell-cycle control, asymmetry/differentiation controls, cellular protective and DNA repair mechanisms, and associated apoptosis/senescence signaling pathways all might be expected to be more highly regulated in stem cells, likely by similar mechanisms. We review the literature to suggest a set of candidate sternness genes that may serve as universal stem cell markers. While we predict many similarities, we also predict that differences will exist between stem cell populations and that when transdifferentiation is considered genes expected to be both similar and different need to be examined. (C) 2004 International Society for Experimental Hematology. Published by Elsevier Inc.
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