Journal
SCIENCE
Volume 305, Issue 5680, Pages 90-93Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1098925
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Funding
- NHLBI NIH HHS [T32-HL07778, HL073742, HL63357] Funding Source: Medline
- NIDDK NIH HHS [DK61846] Funding Source: Medline
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Analysis of developmental plasticity of bone marrow - derived cells (BMDCs) is complicated by the possibility of cell-cell fusion. Here we demonstrate that epithelial cells can develop from BMDCs without cell-cell fusion. We use the Cre/lox system together with beta-galactosidase and enhanced green fluorescent protein expression in transgenic mice to identify epithelial cells in the lung, liver, and skin that develop from BMDCs without cell fusion.
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