Journal
SCIENCE
Volume 305, Issue 5680, Pages 93-96Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1097775
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- Fondazione Telethon Funding Source: Custom
- Telethon [E.0982] Funding Source: Medline
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Organelle inheritance is an essential feature of all eukaryotic cells. As with other organelles, the Golgi complex partitions between daughter cells through the fission of its membranes into numerous tubulovesicular fragments. We found that the protein CtBP3/BARS ( BARS) was responsible for driving the fission of Golgi membranes during mitosis in vivo. Moreover, by in vitro analysis, we identified two stages of this Golgi fragmentation process: disassembly of the Golgi stacks into a tubular network, and BARS-dependent fission of these tubules. Finally, this BARS-induced fission of Golgi membranes controlled the G(2)-to-prophase transition of the cell cycle, and hence cell division.
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