Journal
TETRAHEDRON
Volume 60, Issue 28, Pages 6015-6019Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2004.05.021
Keywords
ophiobolin; marine fungus; Emericella variecolor; cytotoxic; sesterterpene
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Two new sesterterpenes, 6-epi-ophiobolin G (1) and 6-epi-ophiobolin N (3), and six known ophiobolins were isolated from the extracts of the fungus, Emericella variecolor GF10, which was separated from marine sediment. The planar structures of the new compounds were deduced from analysis of the 2D NMR spectra, and the stereochemistry was determined by extensive examination of the NOESY spectrum. Additionally, the configuration of the C-6 proton in ophiobolin G (2) was revised from alpha to beta, and the unsolved stereochemistry of ophiobolin H (4) was determined by its physicochemical evidence and the chemical correlation with ophiobolin K (8). Ophiobolin K (8) showed cytotoxic activity against various tumor cell lines, including adriamycin-resistant mouse leukemia cells (P388), with IC50 of 0.27-0.65 muM. (C) 2004 Elsevier Ltd. All rights reserved.
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