Journal
CHEMBIOCHEM
Volume 5, Issue 7, Pages 937-942Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200300819
Keywords
aminoglycosides; antibiotics; RNA recognition; surface plasmon resonance
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Aminoglycoside antibiotics, which are able to selectively bind to RNA, are considered to be an important lead in RNA-targeting drug discovery. In this study, surface plasmon resonance (SPR) was employed to explore the interaction of aminoglycosides with known tobramycin-binding RNA hairpins (aptamers) and an unrelated RNA hairpin, It was established that aminoglycosides have multiple interactions with RNA hairpins. Unexpectedly, the different hairpins showed comparable affinity for a set of related aminoglycosides. The observed absence of selectivity presents on extra hurdle in the discovery of novel aminoglycosides as specific drugs that target defined RNA hairpins.
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