Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1692, Issue 2-3, Pages 145-157Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2004.02.008
Keywords
integrin; cytoskeleton; Bcl-2; apoptosis; anoikis; amorphosis
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Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Numerous signaling pathways converge to affect the levels and posttranslational modifications of Bcl-2 family proteins. Recent work has defined specific roles for different Bcl-2 proteins in the disruption of mitochondrial function that leads to cell death. Using this understanding of Bcl-2 protein function as a framework, we will consider the molecular mechanisms of apoptosis induced by integrin detachment (anoikis) and cell death stimulated by the loss of cytoskeletal architecture (amorphosis). (C) 2004 Elsevier B.V. All rights reserved.
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