Journal
TETRAHEDRON LETTERS
Volume 45, Issue 28, Pages 5477-5479Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2004.05.057
Keywords
HIV-protease inhibitor; hydroxyethylene dipeptide isostere; gamma-amino acid derivative; sharpless asymmetric aminohydroxylation
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An enantioselective synthesis of lactone 1, a precursor to the (2R,4S,5S) hydroxyethylene dipeptide isostere and amino acid AHPPA 2 has been accomplished from the common intermediate 5 employing Sharpless asymmetric aminohydroxylation as the key step. (C) 2004 Elsevier Ltd. All rights reserved.
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