☆ 4.5 Article

Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)

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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 14, Issue 13, Pages 3501-3505

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PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2004.04.070

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Categories

Chemistry, Medicinal Chemistry, Organic

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Structurally modified 3-(N-benzylamino)propylphosphonic acid SIP receptor agonists that maintain affinity for S1P(1), and have decreased affinity for S1P(3) are efficacious, but exhibit decreased acute cardiovascular toxicity in rodents than do nonselective agonists. (C) 2004 Elsevier Ltd. All rights reserved.

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