Journal
CANCER LETTERS
Volume 210, Issue 1, Pages 101-109Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/j.canlet.2004.01.006
Keywords
colorectal cancer; p53 mutation; post-operative adjuvant therapy; K-ras mutation
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One hundred and thirty-eight stage II and III colorectal cancer patients were included to evaluate the prognostic significance of genetic markers (including mutations of the p53, K-ras genes, and microsatellite instability) on the response to 5-fluorouracil (FU)-based post-operative adjuvant therapies (PAT). When stratified by PAT and adjusting for other prognostic variables, presence of p53 mutation was associated with a poor outcome (hazard ratio (HR) = 3.1, 95% confidence interval (0), 0.9 - 11.0) among patients without PAT. Our data confirmed that p53 mutation is an independent pre-treatment factor in stage II and III colorectal cancer after curative resection. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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