Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 152, Issue 2, Pages 447-452Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2003.10.008
Keywords
spatial learning; win-stay; multiple memory systems; hippocampus; striatum; working memory; amino acid; NMDA receptor
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The effect of the amino acid D-serine, a partial NMDA receptor agonist, on a delayed match-to-place task in the water maze was examined. Twenty-four male rats were first trained to attain baseline measurements, then administered D-serine or saline. Rats administered D-serine (100 mg/kg, i.p.) before swim trials did not show a decrease in escape latencies, but did show an increase in swim time spent within the previous days' escape platform location.. (C) 2003 Elsevier B.V. All rights reserved.
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