Journal
JOURNAL OF NEUROSCIENCE
Volume 24, Issue 28, Pages 6362-6370Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1205-04.2004
Keywords
psychomotor sensitization; intravenous; rate of infusion; immediate early gene; dopamine reuptake-inhibition; rat
Categories
Funding
- NIDA NIH HHS [R37 DA04294, R37 DA004294, F31 DA14737, K05 DA000473, F31 DA014737, K05 DA00473, T32 DA007267, T32 DA 07267] Funding Source: Medline
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The rapid delivery of drugs of abuse to the brain is thought to promote addiction, but why this occurs is unknown. In the present study, we characterized the influence of rate of intravenous cocaine infusion ( 5 - 100 sec) on three effects thought to contribute to its addiction liability: its ability to block dopamine (DA) uptake, to activate immediate early gene expression, and to produce psychomotor sensitization. Rapid infusions potentiated the ability of cocaine to block DA reuptake, to induce c-fos and arc mRNA expression, especially in mesocorticolimbic regions, and to produce psychomotor sensitization. Thus, the rate at which cocaine is delivered influences both its neurobiological impact and its ability to induce a form of drug experience-dependent plasticity implicated in addiction. We propose that rapidly delivered cocaine may be more addictive, in part, because this more readily induces forms of neurobehavioral plasticity that lead to the compulsive pursuit of drugs.
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