Journal
MACROMOLECULAR BIOSCIENCE
Volume 4, Issue 7, Pages 680-684Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200400031
Keywords
hydrogen bonding; L-pyroglutamic acid; molecular imprinting; molecular imprinted polymer; temperature sensitive
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Weakly cross-linked temperature sensitive imprinted polymer hydrogels that recognize L-pyroglutamic acid (Pga) molecules via multiple-point hydrogen bonding were designed and synthesized. The amount of adsorption for Pga in imprinted hydrogels is 3-4 times higher than that in non-imprinted. The selectivity test of imprinted polymer gels was carried out by using a series of structurally related compounds Pga, pyrrolidine, 2-pyrrolidone, L-proline as substrates. The results show that imprinted polymer gels exhibit high sensitivity, special selectivity and reusability, suggesting that the polymer hydrogels would have an enormous potential for application in controlled drug release and seperation field.
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