Journal
IMMUNOLOGY LETTERS
Volume 94, Issue 3, Pages 163-166Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2004.04.017
Keywords
neutrophils; rejection; transplantation
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Because rejection of allografts is primarily caused by T and B lymphocyte responses to allogenic histocompatibility molecules, the role of innate immunity in organ transplant rejection is often overlooked. However, the very first damages to vascularized organ allografts are caused by ischemia-reperfusion, an inflammatory reaction involving activation of vascular endothelial cells and release of neutrophil chemoattractants. Herein, we review experimental observations suggesting that the early neutrophil influx in organ transplants favors T cell-mediated rejection. (C) 2004 Elsevier B.V. All rights reserved.
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