Journal
OPTICS LETTERS
Volume 29, Issue 14, Pages 1650-1652Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.29.001650
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Funding
- NIBIB NIH HHS [R01 EB000790, EB000790-01A2] Funding Source: Medline
- NINDS NIH HHS [NS41291-01] Funding Source: Medline
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Laminar optical tomography (LOT) is a new technique that combines the advantages of diffuse optical tomography image reconstruction and a microscopy-based setup to allow noncontact imaging with 100-200-mum resolution effective over depths of 0-2.5 mm. LOT is being developed primarily for multispectral imaging of rat cortex, for which resolving functional dynamics in various layers of the brain's cortex (to depths of 1500 mum) is of increasing interest to neurophysiologists. System design and image reconstruction techniques are described, along with simulation and phantom results that demonstrate the characteristics and limitations of system accuracy and resolution. (C) 2004 Optical Society of America.
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