Journal
ANALYTICAL CHEMISTRY
Volume 76, Issue 14, Pages 4066-4075Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac049858n
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Aptamer biosensors have been immobilized on beads, introduced into micromachined chips on the electronic tongue sensor array, and used for the detection and quantitation of proteins. Aptamer chips could detect proteins in both capture and sandwich assay formats. Unlike most protein-based arrays, the aptamer chips could be stripped and reused multiple times. The aptamer chips proved to be useful for screening aptamers from in vitro selection experiments and for sensitively quantitating the biothreat agent ricin.
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