Journal
JOURNAL OF PHYSIOLOGY-LONDON
Volume 558, Issue 2, Pages 659-669Publisher
WILEY
DOI: 10.1113/jphysiol.2004.066001
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Mechanosensitive cation channels are thought to be crucial for different aspects of mechano-perception, such as hearing and touch sensation. In the nematode C elegans, the degenerins MEC-4 and MEC-10 are involved in mechanosensation and were proposed to form mechano-sensitive cation channels. Mammalian degenerin homologues, the H+-gated ASIC channels, are expressed in sensory neurones and are therefore interesting candidates for mammalian mechanosensors. We investigated the effect of an ASIC2 gene knockout in mice on hearing and on cutaneous mechanosensation and visceral mechanonociception. However, our data do not support a role of ASIC2 in those facets of mechanoperception.
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