Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 190, Issue 2, Pages 373-378Publisher
UNIV CHICAGO PRESS
DOI: 10.1086/421524
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- NIAID NIH HHS [R01 AI-45969] Funding Source: Medline
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Virus-specific nasal immunoglobulin (Ig) A and serum antibody titers in 67 respiratory syncytial virus (RSV) infected adults were compared with titers in age-matched uninfected control subjects. Control subjects had significantly higher levels of nasal IgA and serum IgG to the RSV F, Ga, and Gb proteins than infected subjects. Serum neutralizing-antibody titers to group A and B RSV strains were also lower in infected subjects, although differences were not as large. Multivariate analysis found that low RSV-specific nasal IgA was an independently significant risk factor for RSV infection.
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