Journal
JOURNAL OF IMMUNOLOGY
Volume 173, Issue 2, Pages 715-720Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.173.2.715
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- PHS HHS [41158] Funding Source: Medline
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The recent identification of IL-27 (IL-27p28/EBV-induced gene 3) and IL-27R (WSX-1/gp130) has provided new insights for the biology of IL-6/IL-12 family cytokines. Initial studies indicated that IL-27 can directly regulate T cell functions and suggested an important role for it in promoting Th1 type responses. However, subsequent studies have revealed that IL-27R signaling influences a variety of immune cell types and can inhibit either Th1 or Th2 type responses. Though elucidation of the Jak/STAT signaling pathways activated by IL-27R ligation has unveiled some of the molecular mechanisms used by IL-27 to promote inflammation, little is known about-the antiinflammatory activities of this cytokine. Thus, the aim of this review is to discuss the pleotropic nature of the IL-27/IL-27R interaction and. attempt to reconcile the pro- and anti-inflammatory properties of this immunomodulator.
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