Journal
JOURNAL OF IMMUNOLOGY
Volume 173, Issue 2, Pages 1158-1165Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.173.2.1158
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- NIAID NIH HHS [R01-AI43576] Funding Source: Medline
- PHS HHS [R01-50659] Funding Source: Medline
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We have identified two intronic regions of mouse prdm1, the gene encoding B lymphocyte-induced maturation protein-1 (Blimp-1), which confer transcriptional repression in response to Bcl-6. The Bcl-6 response element in intron 5, which is conserved between mice and humans, was studied in detail. It binds Bcl-6 in vitro and was shown by chromatin immunoprecipitation to be occupied by Bcl-6 in vivo. Neither Bcl-6 response element functions as a STAT3-response element, showing that STAT3 does not compete with Bcl-6 at these sites. Bel-6(-/-) mice confirm the biological importance of Bcl-6-dependent repression of prdm1. These mice have elevated Ab response, increased Ig-secreting cells, and increased Blimp-1(+) cells in spleen following immunization and their splenic B cells show accelerated plasmacytic development in vitro.
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