Journal
BRAIN RESEARCH
Volume 1014, Issue 1-2, Pages 251-254Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2004.04.037
Keywords
NPY mRNA; central nucleus of amygdala; alcohol preference; anxiety
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Funding
- NIAAA NIH HHS [AA07611, AA13521] Funding Source: Medline
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Levels of neuropeptide Y (NPY) mRNA expression in discrete brain regions of alcohol preferring (P) rats and alcohol nonpreferring (NP) rats were examined using in situ hybridization. NPY mRNA expression was significantly lower in the central nucleus of amygdala (CeA) of P rats than NP rats, whereas no differences were found in the media] or basolateral amygdaloid nuclei. This study suggests that reduced NPY gene expression in the CeA may contribute to differences in alcohol preference and other behavioral differences observed between P and NP rats. (C) 2004 Elsevier B.V. All rights reserved.
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