Journal
FEBS LETTERS
Volume 570, Issue 1-3, Pages 93-96Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2004.06.032
Keywords
malaria parasite; glucose transport; glycolysis; pH regulation; H+-pumping ATPase
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An O-3-hexose derivative, shown previously to inhibit a malaria parasite hexose transporter expressed in Xenopus oocytes as well as to suppress the multiplication of parasites, both in vitro and in vivo, was shown here to block the uptake of hexose sugars into isolated blood-stage parasites. This led to a decline in ATP levels and the loss of intracellular pH control. The results are consistent with those obtained with the cloned transporter. They support the notion that the transporter mediates uptake of glucose into the intraerythrocytic parasite and provide further support for the view that it is a suitable antimalarial drug target. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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