Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 14, Issue 14, Pages 3683-3686Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2004.05.013
Keywords
angiogenesis; antiangiogenesis; artemisinin; exo-olefinated deoxoartemisinin
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10-exo-Bromoalkylidene and benzylidene deoxoarternisinin derivatives with antiangiogenic activity were synthesized from corresponding 10-alkanesulfonyl dihydroartemisinin and 10-phenylmethanesulfonyl dihydroartemisinin using a highly efficient, mild, and simple Ramberg-Backlund rearrangement. (C) 2004 Elsevier Ltd. All rights reserved.
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