Journal
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
Volume 75, Issue 1-2, Pages 57-61Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotobiol.2004.05.007
Keywords
comet assay; kinetics; ultraviolet radiation; EGCG; quercetin; N-acetyleysteine
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Comet assay data (tail DNA %) have been gathered for the concentration dependent role of three antioxidants (AOs); quercetin (Q), epigallocatechin gallate (EGCG) and N-acetylcysteine (NAC) in reducing UV-induced damage to DNA in normal fetal lung fibroblasts (MRC5). All three compounds demonstrate a concentration dependent reduction maximum with a pro-oxidant effect at higher (though not cytotoxic) concentrations. Manipulation of a simple 4-step reaction mechanism for free radical (FR) scavenging by AOs produced rate constant ratios which allowed the relative effectiveness (Q > EGCG > NAC) of the AOs to be evaluated. (C) 2004 Elsevier B.V. All rights reserved.
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