Journal
DEVELOPMENTAL BRAIN RESEARCH
Volume 151, Issue 1-2, Pages 199-202Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.devbrainres.2004.04.004
Keywords
growth/differentiation factor-5; transfonning growth factor-beta s; bone morphogenctic protein; dopaminergic neuron; Parkinson's disease
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Expression of the dopaminergic neurotrophin GDF-5 in developing rat ventral mesencephalon (VM) was found to begin at embryonic day (E) 12 and peak on E14, when dopaminergic neurones undergo terminal differentiation. In the adult rat, GDF-5 was found to be restricted to heart and brain, being expressed in many areas of the brain, including striatum and midbrain. This indicates a role for GDF-5 in the development and maintenance of dopaminergic neurones. (C) 2004 Elsevier B.V. All rights reserved.
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