Journal
EMBO JOURNAL
Volume 23, Issue 14, Pages 2707-2712Publisher
WILEY
DOI: 10.1038/sj.emboj.7600292
Keywords
Cbl; endocytosis; signal transduction; Tsg101; ubiquitin
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Most growth factors control cellular functions by activating specific receptor tyrosine kinases (RTKs). While overactivation of RTK signalling pathways is strongly associated with carcinogenesis, it is becoming increasingly clear that impaired deactivation of RTKs may also be a mechanism in cancer. A major deactivation pathway, receptor downregulation, involves ligand-induced endocytosis of the RTK and subsequent degradation in lysosomes. A complex molecular machinery that uses the small protein ubiquitin as a key regulator assures proper endocytosis and degradation of RTKs. Here we discuss evidence that implicates deregulation of this machinery in cancer.
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