Journal
NEURON
Volume 43, Issue 2, Pages 183-191Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2004.06.024
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Funding
- NEI NIH HHS [R01 EY10257, R01 EY010257] Funding Source: Medline
- NINDS NIH HHS [R01 NS004270, NS04270, P01 NS016033-20, P01 NS016033] Funding Source: Medline
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Axons dictate whether or not they will become myelinated in both the central and peripheral nervous systems by providing signals that direct the development of myelinating glia. Here we identify the neurotrophin nerve growth factor (NGF) as a potent regulator of the axonal signals that control myelination of TrkA-expressing dorsal root ganglion neurons (DRGs). Unexpectedly, these NGF-regulated axonal signals have opposite effects on peripheral and central myelination, promoting myelination by Schwann cells but reducing myelination by oligodendrocytes. These findings indicate a novel role for growth factors in regulating the receptivity of axons to myelination and reveal that different axonal signals control central and peripheral myelination.
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