Journal
NEUROSCIENCE LETTERS
Volume 365, Issue 3, Pages 223-227Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2004.05.004
Keywords
Alzheimer's disease; AD; vascular; beta-amyloid; cerebral blood volume; CBV
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Funding
- NCI NIH HHS [CA 85594] Funding Source: Medline
- NIA NIH HHS [AG 17490, AG 08702, AG 16736, AG 16223] Funding Source: Medline
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Recent advance in nuclear magnetic resonance (NMR) microimaging has enabled in vivo cerebral blood volume (CBV) mapping with high spatial resolution. Using an intravascular susceptibility contrast agent and T-2-weighted magnetic resonance imaging (MRI) on a 9.4 T NMR microimager, the regional CBV was measured in mice as the transverse relaxation increase induced by the contrast agent. CBV maps in an Alzheimer's disease mouse model at resting state were obtained and examined. Four-month-old male transgenic mutant APP (V717F, K670N/M671L) mice (N = 10) and littermate wild-type controls (N = 12) were used. Regional analysis of the multi-slice CBV maps revealed statistically significant CBV reductions among the APP mice in cerebral cortex (-9.29%, P = 0.0002), hippocampus (-4.22%, P = 0.02), and thalamus (-5.21% P = 0.03), indicating an early change of microvasculature in these selected regions. No significant difference was found in olfactory bulb, pons, midbrain, superior colliculus, medulla, and cerebellum. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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