Journal
BIOESSAYS
Volume 26, Issue 8, Pages 821-824Publisher
WILEY
DOI: 10.1002/bies.20082
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Funding
- NIGMS NIH HHS [GM046833] Funding Source: Medline
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X chromosome inactivation is the mammalian answer to the dilemma of dosage compensation between males and females. The study of this fascinating form of chromosome-wide gene regulation has yielded surprising insights into early development and cellular memory. In the past few months, three papers((1-3)) reported unexpected findings about the paternal X chromosome (X-P). All three studies agree that the X-P is imprinted to become inactive earlier than ever suspected during embryonic development. Although apparently incomplete, this early form of inactivation insures dosage compensation throughout development. Silencing of the X-P persists in cells of extraembryonic tissues, but it is erased and followed by random X inactivation in cells of the embryo proper. These findings challenge several aspects of the current view of X inactivation during early development and may have profound impact on studies of pluripotency and epigenetics. (C) 2004 Wiley Periodicals, Inc.
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