Journal
TRENDS IN CELL BIOLOGY
Volume 14, Issue 8, Pages 452-460Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2004.07.008
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Intercellular fusion among myoblasts; is required for the generation of multinucleated muscle fibers during skeletal muscle development. Recent studies in Drosophila have shed light on the molecular mechanisms that underlie this process, and a signaling pathway that relays fusion signals from the cell membrane to the cytoskeleton has emerged. In this article, we review these recent advances and discuss how Drosophila offers a powerful model system to study myoblast fusion in vivo.
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