Journal
JOURNAL OF NEURO-ONCOLOGY
Volume 69, Issue 1-3, Pages 101-117Publisher
SPRINGER
DOI: 10.1023/B:NEON.0000041874.02554.b3
Keywords
brain delivery methods; convection-enhanced delivery; gene therapy; immunotoxins; oncolytic virus; toxins; viral therapy
Categories
Ask authors/readers for more resources
Local delivery of biologic agents, such as gene and viruses, has been tested preclinically with encouraging success, and in some instances clinical trials have also been performed. In addition, the positive pressure infusion of various therapeutic agents is undergoing human testing and approval has already been granted for routine clinical use of biodegradable implants that diffuse a chemotherapeutic agent into peritumoral regions. Safety in glioma patients has been shown, but anticancer efficacy needs additional refinements in the technologies employed. In this review, we will describe these modalities and provide a perspective on needed improvements that should render them more successful.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available