Journal
NEUROGASTROENTEROLOGY AND MOTILITY
Volume 16, Issue 4, Pages 383-394Publisher
WILEY
DOI: 10.1111/j.1365-2982.2004.00513.x
Keywords
opioid; opiate; receptor; sensation; mobility; absorption
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This article reviews the pharmacology and physiology of opiate receptors and the current and potential uses of opioid agonists and antagonists in clinical gastroenterology. mu-receptors are involved in motor and sensory functions, and their modulation is established for treatment of diarrhea. mu-antagonists have potential to reverse endogenous (e.g., postoperative ileus) or iatrogenic dysmotility (e.g., opioid bowel dysfunction). Modulation of the function of kappa-receptors may be a novel approach to control visceral pain in functional gut disorders. Results of formal testing of novel opioid modulators are keenly awaited.
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