Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 16, Issue 4, Pages 524-530Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2004.05.009
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Theileria parasites infect and transform cells of the ruminant immune system. Continuous proliferation and survival of Theileria-transformed cells involves the well-orchestrated activation of several host-cell signalling pathways. Constitutive NF-kappaB (nuclear factor kappaB) activation is accomplished by recruiting the IKK (IkappaB kinase) complex, a central regulator of NF-kappaB pathways, to the surface of the transforming schizont, where it becomes permanently activated. Constitutive activation of the PI-3K-PKB [phosphoinositide 3-kinase-(Akt), protein kinase B] pathway is likely to be indirect and is essential for continuous proliferation. Theileria-transformed T cells express a range of anti-apoptotic proteins that can be expected to provide protection against apoptosis induced by death receptors, as well as cellular control mechanisms that are mobilised to eliminate cells that entered a cycle of uncontrolled proliferation.
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