Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 61, Issue 16, Pages 2010-2019Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-004-4050-y
Keywords
phosphinic; inhibitors; zinc proteases; transition-state; ACE; MMPs
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Solid-phase synthesis of phosphinic peptides was introduced 10 years ago. A major application of this chemistry has been the development of potent synthetic inhibitors of zinc metalloproteases. Specific properties of the inhibitors produced in recent years are reviewed, supporting the notion that phosphinic pseudo-peptides are useful tools for studying the structural and functional biology of zinc proteases.
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