Journal
APPLIED SURFACE SCIENCE
Volume 256, Issue 22, Pages 6489-6494Publisher
ELSEVIER
DOI: 10.1016/j.apsusc.2010.04.044
Keywords
Mesoporous silica; Naproxen; Controlled release; Drug delivery
Categories
Funding
- Slovak Research and Development Agency [APVV-6RPEU-0027-06]
- Ministry of Education of the Slovak Republic [1/0119/08]
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In this paper, we present the release of naproxen from hexagonal periodic mesoporous silica SBA-15, which serves as a drug delivery system. Naproxen, the well-known nonsteroidal anti-inflammatory drug (NSAID), was loaded into the pores of SBA-15 silica modified with aminopropyl groups. The physicochemical properties of the modified sample (A-SBA-15/napro) were compared with the unmodified SBA-15 mesoporous silica loaded with the drug (SBA-15/napro). The kinetic of the naproxen release into the physiological solution was studied. The released amount of naproxen represented 90.7% from the unmodified SBA-15 in 72 h, while from the sample A-SBA-15/napro the released amount represented about 80.9%. The prepared materials were characterized by nitrogen adsorption/desorption, Small angle X-ray scattering (SAXS), Fourier-transform infrared spectroscopy (FT-IR) and the thermoanalytical methods (TG/DTA). Thin layer chromatography (TLC) was used for quantitative determination of the released naproxen. (C) 2010 Elsevier B.V. All rights reserved.
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