Journal
CLINICAL MICROBIOLOGY AND INFECTION
Volume 10, Issue 8, Pages 757-760Publisher
ELSEVIER SCI LTD
DOI: 10.1111/j.1469-0691.2004.00913.x
Keywords
bla(IBC-1); bla(VIM-2); carbapenemase; Escherichia coli; metallo-beta-lactamase; resistance
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An Escherichia coli strain with decreased susceptibility to carbapenems was isolated from a hospitalised patient in Athens, Greece. The strain was resistant to all beta-lactarns, including aztreonam, whereas the MIC of imipenem and meropenem was 0.5 mg/L. A positive EDTA-disk synergy test suggested the production of a metallo-beta-lactamase. PCR experiments revealed the presence of the bla(VIM-2), bla(IBC-1) and bla(TEM-1) genes. Resistance to beta-lactams was not transferable by conjugation. This is the first report of a clinical isolate of E. coli producing VIM-2, and the first report of the coexistence of bla(VIM-2) and bla(IBC-1) in a single clinical isolate.
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