Journal
JOURNAL OF NATURAL PRODUCTS
Volume 67, Issue 8, Pages 1415-1418Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np0499620
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Funding
- NCI NIH HHS [CA 52955] Funding Source: Medline
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Three new chlorinated diterpenes, 6-8, along with five known ones, 1-5, were isolated from the molluscs Pleurobranchus albiguttatus and P. forskalii collected in the Philippines. These diterpenes are presumably metabolites of a Lissoclinum species of ascidian on which the molluscs have fed. The structures of the new compounds were determined by interpretation of their spectral data. Compounds 1 and 2 were found to be potent cytotoxins in the National Cancer Institute's screening panel of 60 tumor cell lines and showed some selectivity for melanomas. Two other samples exhibited solid tumor selectivity in a soft agar disk diffusion assay.
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