Journal
MITOCHONDRION
Volume 4, Issue 4, Pages 285-308Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2004.05.007
Keywords
fission; fusion; distribution; morphogenesis; apoptosis
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Mitochondrial undergo regulated fusion and division in many organisms and cell types, and each event is mediated by a different complex of proteins each containing at least one large GTPase. The mitochondrial fusion and division molecular machinery is in large part conserved; recent studies show a functional connection between some of these proteins and the apoptotic cascade. Mitochondria also undergo directed movement in cells, and the gene products that attach and propel mitochondria along cytoskeletal elements (actin filaments in some organisms, microtubules in others) are becoming gradually elucidated. (C) 2004 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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