Journal
GROWTH HORMONE & IGF RESEARCH
Volume 14, Issue 4, Pages 261-269Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.ghir.2004.01.005
Keywords
IGF-I; breast cancer; cancer risk; growth hormone
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Funding
- NCI NIH HHS [R01 CA74285, R01 CA89652, P30 CA77398] Funding Source: Medline
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Growth factor pathways are fundamental in normal tissue regulation and development. In many tissues, factors that function in normal growth and development also have important regulatory roles in transformed malignant cells. The insulin-like growth factor (IGF) system is implicated in the regulation of the malignant phenotype by its effects on proliferation, differentiation, and apoptosis. IGF-I has also been linked to malignant transformation. The role of the IGF-I in cancer has been recognized in both experimental and clinical settings, suggesting that the enhancement of growth factor pathways potentially could increase the risk for cancer development. In this paper, the role of IGF-I signaling in tumor regulation, and the impact of IGF-I modulation using growth hormone replacement therapy are discussed. (C) 2004 Published by Elsevier Ltd.
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