Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 48, Issue 8, Pages 2838-2844Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.48.8.2838-2844.2004
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Funding
- NCI NIH HHS [CA 21765, P30 CA021765] Funding Source: Medline
- NIGMS NIH HHS [R01 GM034496, GM 34496, R37 GM034496] Funding Source: Medline
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We have generated a database of expression profiles carrying the transcriptional responses of the model organism Bacillus subtilis following treatment with 37 well-characterized antibacterial compounds of different classes. The database was used to build a predictor for the assignment of the mechanisms of action (MoAs) of antibacterial compounds by the use of support vector machines. This predictor was able to correctly classify the MoA class for most compounds tested. Furthermore, we provide evidence that the in vivo MoA of hexachlorophene does not match the MoA predicted from in vitro data, a situation frequently faced in drug discovery. A database of this kind may facilitate the prioritization of novel antibacterial entities in drug discovery programs. Potential applications and limitations are discussed.
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