Studies on the synthesis and characterization of four trans-planaramineplatinum(II) complexes of the form trans-PtL(NH3)CL2 where L=2-hydroxypyridine, 3-hydroxypyridine, imidazole, and imidazo(1,2-α)pyridine

Four trans-planaramineplatinum(II) complexes code named YH9, YH10, YH11 and YH12, each of the form trans-PtL(NH3)Cl-2 where L = 2-hydroxypyridine and 3-hydroxypyridine, imidazole, and imidazo(1,2-alpha)pyridine for YH9, YH10, YH11 and YH12, respectively. All of the compounds have significant anticancer activity against human cancer cell lines. YH12 is found to be significantly more active than cisplatin,R against cisplatin-resistant ovary cell line A2780(cisR). (C) 2004 Elsevier SAS. All rights reserved.