Journal
NATURAL PRODUCT RESEARCH
Volume 18, Issue 4, Pages 295-299Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786410310001620691
Keywords
Alnus japonica; Curcuma longa; farnesyl protein transferase; diarylheptanoids
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Diarylheptanoids [curcumin (1), demethoxycurcumin (2), bisdemethoxycurcumin (3), bisdimethoxymethylcurcumin (4), and 1,2-dihydrobis(de-O-methyl)curcumin (5)] were isolated from the methanolic extract of Curcuma longa L. and a new cyclic diarylheptanoid (6) and a known Compound 7 were isolated from fruits of Alnus japonica Steud. Diarylheptanoids (1-3) inhibited farnesyl protein transferase (FPTase) with an IC50 of 29-50 muM. The other compounds very mildly inhibited FPTase, therefore, the inhibitory activity on FPTase very much depends on the structure of diarylheptanoids.
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