Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 16, Issue 4, Pages 343-349Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2004.06.012
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The endoplasmic reticulum (ER) is a highly versatile protein factory that is equipped with chaperones and folding enzymes essential for protein folding. ER quality control guided by these chaperones is essential for life. Whereas correctly folded proteins are exported from ER, misfolded proteins are retained and selectively degraded. At least two main chaperone classes, BiP and calnexin/calreticulin, are active in ER quality control. Folding factors usually are found in complexes. Recent work emphasises more than ever that chaperones act in concert with co-factors and with each other.
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