Journal
AMERICAN JOURNAL OF HEMATOLOGY
Volume 76, Issue 4, Pages 389-394Publisher
WILEY
DOI: 10.1002/ajh.20111
Keywords
donor cell; myelodysplastic syndrome; allogeneic stem cell transplantation; donor lymphocyte infusion
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Allogeneic hematopoletic stem cell transplantation (SCT) is a potentially curative treatment for patients with myelodysplastic syndrome (MDS). Relapses after transplantation however, are not uncommon and are usually due to re-emergence of a recipient derived, neoplastic, stem cell clone. We report a unique case of MDS recurring 5 months after non-myeloablative, sibling, allogeneic SCT. Interestingly, chimerism analysis at relapse showed hematopoiesis to be entirely of donor origin confirming donor cell MDS. Donor lymphocyte infusion (DLI) produced a hematological response lasting several months. Our review of the literature shows donor-derived MDS to be very rare, with only four such cases described previously. In this report, we describe the details of our case and discuss putative mechanisms underlying the genesis of donor cell MDS and the observed response to DLI. (C) 2004 Wiley-Liss, Inc.
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