The application of new nanocomposites: Enhancement effect of polylactide nanofibers/nano-TiO2 blends on biorecognition of anticancer drug daunorubicin

In this contribution, the blending of nano-titanium dioxide (TiO2) and polylactide (PLA) nanofibers has been adopted as a new nanomaterial to facilitate the biorecognition of an anticancer drug daunorubicin. Our observations demonstrate that upon application of the nano-TiO2-PLA polymer nanocomposites, the drug molecules could be readily self-assembled on the surface of the new nanocomposites so that considerably enhanced detection sensitivity for the DNA binding behavior could be observed for the relative biorecognition. These results may also imply some potential valuable application of the blending of nano-TiO2 and PLA nanofibers as a kind of drug carriers in view of the respective good biocompatibility and large surface area of the new nanocomposites. (c) 2008 Elsevier B.V. All rights reserved.