Journal
EXPERT OPINION ON BIOLOGICAL THERAPY
Volume 4, Issue 8, Pages 1213-1224Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712598.4.8.1213
Keywords
block co-polymers; chitosan; gene delivery; lipid; microparticle; nanoparticle; PLGA; polyethylenimines
Funding
- NHLBI NIH HHS [1R01HL71101-01A2] Funding Source: Medline
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With the development of genomic and proteomic technologies, the prospect for gene therapy has progressed rapidly. This has been partly possible due to the emergence of a diverse array of polymeric and non-polymeric nanoparticles that are being investigated for their ability to deliver genes and drugs. in this review, particles have been pragmatically divided as chitosan-related and chitosan-unrelated nanomaterials. The state of the art in terms of the development, characterisation and evaluation of their in vitro and/or in vivo potential is discussed for each of these various particles. Although substantial progress has been made, the potential of these particles in the clinical arena and human responses remain to be evaluated. it is hoped that this review will provide an impetus for further studies of these particles, with the ultimate intent that one or more of these diverse nanoparticle-based non-viral approaches for gene transfer will translate from 'bench to bedside' in the future.
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