Journal
ENVIRONMETRICS
Volume 15, Issue 5, Pages 501-512Publisher
WILEY
DOI: 10.1002/env.683
Keywords
death; disease progression; environmetrics; exposure risk; first hitting time; health status; latent process; lung cancer; stochastic process; survival analysis; Wiener process; work environment
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Funding
- NCI NIH HHS [R01 CA079725-03, R01 CA079725-01A1, R01 CA079725-02] Funding Source: Medline
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This article examines the application of a first hitting time (FHT) model, using an operational time scale, to assess mortality risk differentials of the work environment. A major case application is presented that applies the model to three job categories of railroad workers. The data set involves a study of more than 50000 workers with mortality assessed from 1959 to 1996. Lung cancer mortality was assessed because of a suspected link to diesel exhaust exposure. Based on a model that stipulates that death occurs when the disease state of a subject first hits a threshold value, the FHT model provides insights into factors influencing disease progression. In this application, in particular, the findings suggest that a job category in 1959 alters the risk of death from lung cancer. Copyright (C) 2004 John Wiley Sons, Ltd.
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