Journal
IMMUNOLOGICAL REVIEWS
Volume 200, Issue -, Pages 156-164Publisher
WILEY
DOI: 10.1111/j.0105-2896.2004.00160.x
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Funding
- NCI NIH HHS [CA097096] Funding Source: Medline
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The nonhomologous end-joining pathway is a major means for repairing double-strand breaks (DSBs) in all mitotic cell types. This repair pathway is also the only efficient means for resolving DSB intermediates in V(D)J recombination, a lymphocyte-specific genome rearrangement required for assembly of antigen receptors. A role for polymerases in end-joining has been well established. They are a major factor in determining the character of repair junctions but, in contrast to 'core' end-joining factors, typically appear to have a subtle impact on the efficiency of end-joining. Recent work implicates several members of the Pol X family in end-joining and suggests surprising complexity in the control of how these different polymerases are employed in this pathway.
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